|
KMID : 0381219910230010006
|
|
Journal of RIMSK
1991 Volume.23 No. 1 p.6 ~ p.12
|
|
|
Neuropeptides in Human Airway
|
|
|
|
|
Abstract
|
|
|
|
Sevral neuropepitds as biologically active peptides have now been identified in human airways. Many of these peptides have potent effects on several aspects of airway function, smooth muscle tone, airway secretion, bronchial blood flow and microvascular leakage. Vasoactive intestinal peptide and peptide histidine methionine are potent relaxants of human airways. Sensory neuropeptides such as substance P, neurokinins and calcitonin gene-related peptides may be involved in neurogenic inflammations in bronchial asthma. Now these peptids are suggested as neurotransmitters or neuromodulators of nonadrenergic noncholinegic nerves and classic autonomic nerves in human airways. Neuropeptides may play some pathophysiologic roles in bronchial asthma, but their roles in the physiologic control of airway function is difficult to detect because their airway effects are relatively small and overshadowed by their potent cardiovascular actions. Thus the development of safe specific antagonists will make helpful in further understanding of the pathophysiologic role and useful in human airway diseases such as bronchial asthma.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|